diff --git a/.github/workflows/main.yml b/.github/workflows/main.yml
index 6a6af592a4..ca80d6befd 100644
--- a/.github/workflows/main.yml
+++ b/.github/workflows/main.yml
@@ -23,11 +23,14 @@ jobs:
           echo -e "$CONCURRENCY_GROUP\n"
         shell: bash
       - uses: actions/checkout@v4
-      - uses: actions/setup-python@v5
+      - uses: astral-sh/setup-uv@v7
         with:
           python-version: "3.12"
+          activate-environment: true
+          enable-cache: true
+          cache-python: true
       - run: |
-          pip install -U --group lint
+          uv pip install -U --group lint
       - uses: dtolnay/rust-toolchain@1.92 # TODO: unpin clippy
         with:
           components: rustfmt, clippy
@@ -75,6 +78,13 @@ jobs:
             python-version: "3.12"
             platform: { os: "ubuntu-latest", python-architecture: "x64", rust-target: "x86_64-unknown-linux-gnu" }
             msrv: "MSRV"
+          # Test Python 3.12 on additional Linux architectures
+          - rust: stable
+            python-version: "3.12"
+            platform: { os: "ubuntu-24.04-ppc64le", python-architecture: "ppc64le", rust-target: "powerpc64le-unknown-linux-gnu" }
+          - rust: stable
+            python-version: "3.12"
+            platform: { os: "ubuntu-24.04-s390x", python-architecture: "s390x", rust-target: "s390x-unknown-linux-gnu" }
           # Test future versions of Rust and Python
           - rust: beta
             python-version: "3.14" # upgrade to 3.15-dev when the release candidate is available
@@ -83,11 +93,12 @@ jobs:
     steps:
       - uses: actions/checkout@v4
       - name: Set up Python ${{ matrix.python-version }}
-        uses: actions/setup-python@v5
+        uses: astral-sh/setup-uv@v7
         with:
           python-version: ${{ matrix.python-version }}
-          architecture: ${{ matrix.platform.python-architecture }}
-
+          activate-environment: true
+          enable-cache: true
+          cache-python: true
       - name: Install Rust toolchain
         uses: dtolnay/rust-toolchain@master
         with:
@@ -95,7 +106,7 @@ jobs:
           targets: ${{ matrix.platform.rust-target }}
       - name: 'Install dependencies'
         run: |
-          python -m pip install -U --group testinfra
+          uv pip install -U --group testinfra
       - name: 'Install binary dependencies'
         run: sudo apt-get install -y graphviz
         if: runner.os == 'Linux'
@@ -112,15 +123,17 @@ jobs:
     steps:
       - uses: actions/checkout@v4
       - name: Set up Python ${{ matrix.python-version }}
-        uses: actions/setup-python@v5
+        uses: astral-sh/setup-uv@v7
         with:
           python-version: ${{ matrix.python-version }}
-          architecture: x64
+          activate-environment: true
+          enable-cache: true
+          cache-python: true
       - name: Install Rust toolchain
         uses: dtolnay/rust-toolchain@stable
       - name: 'Install dependencies'
         run: |
-          python -m pip install -U --group testinfra
+          uv pip install -U --group testinfra
       - name: 'Run rustworkx stub tests'
         run: nox -estubs
   coverage:
@@ -130,10 +143,13 @@ jobs:
     runs-on: ubuntu-latest
     steps:
       - uses: actions/checkout@v4
-      - name: Set up Python ${{ matrix.python-version }}
-        uses: actions/setup-python@v5
+      - name: Set up Python 3.12
+        uses: astral-sh/setup-uv@v7
         with:
           python-version: "3.12"
+          activate-environment: true
+          enable-cache: true
+          cache-python: true
       - name: Install Rust toolchain
         uses: dtolnay/rust-toolchain@stable
         with:
@@ -142,9 +158,9 @@ jobs:
         run: curl -L https://github.com/mozilla/grcov/releases/download/v0.8.7/grcov-x86_64-unknown-linux-gnu.tar.bz2 | tar jxf -
       - name: Install deps
         run: |
-          pip install -U --group test
+          uv pip install -U --group test
       - name: Build rustworkx
-        run: pip install .
+        run: uv pip install .
         env:
           SETUPTOOLS_RUST_CARGO_PROFILE: "dev"
           CARGO_INCREMENTAL: 0
@@ -178,17 +194,20 @@ jobs:
       - uses: actions/checkout@v4
         with:
           fetch-depth: 0
-      - name: Set up Python ${{ matrix.python-version }}
-        uses: actions/setup-python@v5
+      - name: Set up Python 3.12
+        uses: astral-sh/setup-uv@v7
         with:
           python-version: "3.12"
+          activate-environment: true
+          enable-cache: true
+          cache-python: true
       - name: Install Rust toolchain
         uses: dtolnay/rust-toolchain@stable
       - name: Install binary deps
         run: sudo apt-get install -y graphviz
       - name: Install deps
         run: |
-          pip install -U --group testinfra
+          uv pip install -U --group testinfra
       - name: Build Docs
         run: nox -e docs
       - uses: actions/upload-artifact@v4
diff --git a/.github/workflows/wheels.yml b/.github/workflows/wheels.yml
index f8842c5e28..a1ec30456e 100644
--- a/.github/workflows/wheels.yml
+++ b/.github/workflows/wheels.yml
@@ -91,7 +91,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        os: [ubuntu-latest]
+        os: [ubuntu-24.04-ppc64le]
     steps:
       - uses: actions/checkout@v4
       - uses: actions/setup-python@v5
@@ -99,10 +99,6 @@ jobs:
         with:
           python-version: '3.12'
       - uses: dtolnay/rust-toolchain@stable
-      - name: Set up QEMU
-        uses: docker/setup-qemu-action@v2
-        with:
-          platforms: all
       - name: Install cibuildwheel
         run: |
           python -m pip install -U --group releaseinfra
@@ -129,7 +125,7 @@ jobs:
     strategy:
       fail-fast: false
       matrix:
-        os: [ubuntu-latest]
+        os: [ubuntu-24.04-s390x]
     steps:
       - uses: actions/checkout@v4
       - uses: actions/setup-python@v5
@@ -137,10 +133,6 @@ jobs:
         with:
           python-version: '3.12'
       - uses: dtolnay/rust-toolchain@stable
-      - name: Set up QEMU
-        uses: docker/setup-qemu-action@v2
-        with:
-          platforms: all
       - name: Install cibuildwheel
         run: |
           python -m pip install -U --group releaseinfra