diff --git a/config/inference/base.yaml b/config/inference/base.yaml
index 3bb0a5c1..686e71bf 100644
--- a/config/inference/base.yaml
+++ b/config/inference/base.yaml
@@ -11,6 +11,7 @@ inference:
   model_only_neighbors: False
   output_prefix: samples/design
   write_trajectory: True
+  empty_cache_per_design: False
   scaffold_guided: False
   model_runner: SelfConditioning
   cautious: True
diff --git a/scripts/run_inference.py b/scripts/run_inference.py
index 3fb6466e..3ebb5e3f 100755
--- a/scripts/run_inference.py
+++ b/scripts/run_inference.py
@@ -188,6 +188,9 @@ def main(conf: HydraConfig) -> None:
                 chain_ids=sampler.chain_idx,
             )
 
+        if conf.inference.empty_cache_per_design and torch.cuda.is_available():
+            torch.cuda.empty_cache()
+
         log.info(f"Finished design in {(time.time()-start_time)/60:.2f} minutes")