diff --git a/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-1.06-GCC-13.2.0.eb b/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-1.06-GCC-13.2.0.eb
new file mode 100644
index 000000000000..7e990fa54d85
--- /dev/null
+++ b/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-1.06-GCC-13.2.0.eb
@@ -0,0 +1,63 @@
+easyblock = 'MakeCp'
+
+name = 'MetaGeneMark-2'
+version = '1.06'
+
+homepage = 'https://github.com/gatech-genemark/MetaGeneMark-2'
+description = """MetaGeneMark-2 is an unsupervised metagenomic gene finder.
+It improves on MetaGeneMark by adding models for better gene start prediction,
+as well as automatic selection of genetic code (4 or 11). The models for gene
+start prediction are based in part on the work done for GeneMarkS-2; they include
+Shine-Dalgarno RBS, non-Shine-Dalgarno (or non-canonical) RBS, and bacterial and
+archaeal promoter models (for use in cases of leaderless transcription).
+"""
+
+toolchain = {'name': 'GCC', 'version': '13.2.0'}
+
+sources = [{
+    'filename': '%(name)s-%(version)s.tar.xz',
+    'git_config': {
+        'url': 'https://github.com/gatech-genemark',
+        'repo_name': '%(name)s',
+        'commit': 'a455a8b48ebc6f681b81202c0760d7830f015fe5',
+    }
+}]
+patches = ['MetaGeneMark-2-fix_Makefile.patch']
+checksums = [
+    {'MetaGeneMark-2-1.06.tar.xz': '0098b905c1b96b2916abdfeb05702e3f7db35c45a4f92d623da295c9cbae3be8'},
+    {'MetaGeneMark-2-fix_Makefile.patch': '6f0fe0fefc053833f394e6ce47fe17596fda552a34e21901fd24d1f60a2d10d0'},
+]
+
+dependencies = [
+    ('Perl', '5.38.0'),
+    ('Boost', '1.83.0'),
+]
+
+build_cmd = ' && '.join([
+    'cd src',
+    'make -f Makefile.ubuntu'
+])
+
+fix_perl_shebang_for = ['bin/run_mgm.pl']
+
+files_to_copy = [
+    (['src/gmhmmp2', 'src/run_mgm.pl'], 'bin'),
+    (['src/*.h', 'src/*.hpp'], 'include'),
+    (['src/mgm2_11.mod', 'src/mgm2_4.mod'], 'lib'),
+]
+
+postinstallcmds = [
+    'chmod a+rx %(installdir)s/bin/run_mgm.pl',
+]
+
+sanity_check_paths = {
+    'files': ['bin/gmhmmp2'],
+    'dirs': ['include']
+}
+
+sanity_check_commands = [
+    'run_mgm.pl | grep seq',
+    'gmhmmp2 --help 2>&1 | grep seq',
+]
+
+moduleclass = 'bio'
diff --git a/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-fix_Makefile.patch b/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-fix_Makefile.patch
new file mode 100644
index 000000000000..8a38465440c7
--- /dev/null
+++ b/easybuild/easyconfigs/m/MetaGeneMark-2/MetaGeneMark-2-fix_Makefile.patch
@@ -0,0 +1,38 @@
+# Author: Ehsan Moravveji (VSC, KU Leuven)
+# Purpose: Fix caveats of Makefile.ubuntu
+
+diff -ruN MetaGeneMark-2-orig/src/Makefile.ubuntu MetaGeneMark-2/src/Makefile.ubuntu
+--- MetaGeneMark-2-orig/src/Makefile.ubuntu	2025-03-11 13:34:45.480535000 +0100
++++ MetaGeneMark-2/src/Makefile.ubuntu	2025-03-11 14:44:41.794798000 +0100
+@@ -12,24 +12,25 @@
+ VER=1.06
+ 
+ CXX = g++
+-CXXFLAGS = -O2 -Wall -I. -I/usr/include/boost/
+-LIBS = -L/usr/lib/ -lboost_program_options -lboost_iostreams 
++CXXFLAGS = -O2 -Wall -I. -I$(EBROOTBOOST)/include/
++LIBS = -L$(EBROOTBOOST)/lib/ -lboost_program_options -lboost_iostreams 
+ LDFLAGS = -lm  -lstdc++  -static
+ 
+ SRCS = main.cpp \
+ 	data_2.cpp model_2.cpp parameter_parser_2.cpp parameters_2.cpp \
+ 	pset_2.cpp sequence_file_2.cpp sequence_map_2.cpp settings_2.cpp \
+-	evidence_2.cpp site_2.cpp output_2.cpp
++	evidence_2.cpp site_2.cpp multi_shift_site.cpp output_2.cpp
+ 
+ OBJS = main.o \
+ 	data_2.o model_2.o parameter_parser_2.o parameters_2.o \
+ 	pset_2.o sequence_file_2.o sequence_map_2.o settings_2.o \
+-	evidence_2.o site_2.o output_2.o
++	evidence_2.o site_2.o multi_shift_site.o output_2.o
+ 
+ HDRS = common_2.h \
+ 	data_2.h index_2.h logfile_2.h memory_mapped_file_2.h model_2.h \
+-	parameter_parser_2.h parameters_2.h pset_2.h exit.h\
+-	sequence_file_2.h sequence_map_2.h settings_2.h evidence_2.h site_2.h output_2.h
++	parameter_parser_2.h parameters_2.h pset_2.h exit.h \
++	sequence_file_2.h sequence_map_2.h settings_2.h evidence_2.h site_2.h \
++	multi_shift_site.hpp output_2.h
+ 
+ .cpp.o:
+ 	$(CXX) -c -o $@ $(CXXFLAGS) $<