diff --git a/spec_pythonizer/requirements.txt b/spec_pythonizer/requirements.txt
index 61e47b9a..8349cd27 100644
--- a/spec_pythonizer/requirements.txt
+++ b/spec_pythonizer/requirements.txt
@@ -1,5 +1,5 @@
 eth-utils>=1.3.0,<2
 eth-typing>=2.1.0,<3.0.0
 oyaml==0.7
-pycryptodome==3.7.3
+pycryptodome==3.19.1
 py_ecc>=1.6.0