diff --git a/modules/nf-neuro/anonymization/pydeface/main.nf b/modules/nf-neuro/anonymization/pydeface/main.nf
new file mode 100644
index 00000000..9f48886b
--- /dev/null
+++ b/modules/nf-neuro/anonymization/pydeface/main.nf
@@ -0,0 +1,89 @@
+process PYDEFACE {
+
+    tag "${meta.subject}_${meta.session}_${nifti.name}"
+
+    container {
+        workflow.containerEngine in ['singularity', 'apptainer'] && !(task.ext.singularity_pull_docker_container ?: false)
+            ? 'docker://poldracklab/pydeface:latest'
+            : 'docker.io/poldracklab/pydeface:latest'
+    }
+
+    containerOptions {
+        workflow.containerEngine == 'docker' ? '--entrypoint ""' : ''
+    }
+
+    cpus   { (params.pydeface_cpus ?: 4) as Integer }
+    memory { params.pydeface_mem ?: '8 GB' }
+    time   { params.pydeface_time ?: '2h' }
+
+    input:
+    tuple val(meta), path(nifti)
+
+    output:
+    tuple val(meta), path("sub-${meta.subject}/ses-${meta.session}/anat/*_defaced.nii.gz"), emit: defaced
+    path("logs/*.log"), emit: logs
+    path "versions.yml", emit: versions, topic: "versions"
+
+    script:
+    """
+    set -euo pipefail
+
+    export OMP_NUM_THREADS="${task.cpus}"
+    export OMP_THREADS="${task.cpus}"
+
+    sub="sub-${meta.subject}"
+    ses="ses-${meta.session}"
+
+    mkdir -p "\$sub/\$ses/anat" logs
+
+    base="\$(basename "${nifti}" .nii.gz)"
+    out_file="\$sub/\$ses/anat/\${base}_defaced.nii.gz"
+
+    log_prefix="sub-${meta.subject}_ses-${meta.session}_\${base}"
+    out_log="logs/\${log_prefix}_out.log"
+    err_log="logs/\${log_prefix}_err.log"
+
+    {
+        echo "=== PYDEFACE ==="
+        echo "INPUT:         ${nifti}"
+        echo "OUTPUT:        \$out_file"
+        echo "CPUS:          ${task.cpus}"
+        echo "OMP_THREADS:   \$OMP_THREADS"
+        echo "DATE:          \$(date -Is)"
+        echo "==============="
+        echo
+    } | tee -a "\$out_log"
+
+        if [[ "\$base" == *"_defaced" ]]; then
+        echo "[SKIP] Input already looks defaced: \$base" | tee -a "\$out_log"
+        cp "${nifti}" "\$out_file"
+    else
+        if [[ -f /shell-hook.sh ]]; then
+            /bin/bash /shell-hook.sh pydeface "${nifti}" --outfile "\$out_file" \\
+                1> >(tee -a "\$out_log") \\
+                2> >(tee >(grep -i -e "warning" -e "error" >> "\$err_log") >&2)
+        elif command -v pydeface >/dev/null 2>&1; then
+            pydeface "${nifti}" --outfile "\$out_file" \\
+                1> >(tee -a "\$out_log") \\
+                2> >(tee >(grep -i -e "warning" -e "error" >> "\$err_log") >&2)
+        elif command -v python3 >/dev/null 2>&1; then
+            python3 -m pydeface "${nifti}" --outfile "\$out_file" \\
+                1> >(tee -a "\$out_log") \\
+                2> >(tee >(grep -i -e "warning" -e "error" >> "\$err_log") >&2)
+        else
+            echo "ERROR: Neither /shell-hook.sh, pydeface nor python3 available in container" >&2
+            exit 127
+        fi
+    fi
+
+    : >> "\$err_log"
+
+    PYDEFACE_VERSION="\$(pydeface --version 2>&1 | grep -oE '[0-9]+[.][0-9]+([.][0-9]+)?' | head -n 1 || true)"
+    [ -z "\$PYDEFACE_VERSION" ] && PYDEFACE_VERSION="unknown"
+
+    cat <<-END_VERSIONS > versions.yml
+    "${task.process}":
+        pydeface: "\$PYDEFACE_VERSION"
+    END_VERSIONS
+    """
+}
diff --git a/modules/nf-neuro/anonymization/pydeface/meta.yml b/modules/nf-neuro/anonymization/pydeface/meta.yml
new file mode 100644
index 00000000..8d86cc85
--- /dev/null
+++ b/modules/nf-neuro/anonymization/pydeface/meta.yml
@@ -0,0 +1,65 @@
+name: "pydeface"
+description: Remove facial structures from MRI NIfTI images using PyDeface.
+keywords:
+  - neuroimaging
+  - MRI
+  - NIfTI
+  - anonymization
+  - defacing
+authors:
+  - "@loboehme1"
+maintainers:
+  - "@loboehme1"
+input:
+  - - meta:
+        type: map
+        description: |
+          Groovy Map containing sample information.
+          Expected keys for this module currently include `subject` and `session`,
+          for example `[ subject: '01', session: '001' ]`.
+    - nifti:
+        type: file
+        description: |
+          Input anatomical MRI image in NIfTI format.
+        pattern: "*.{nii,nii.gz}"
+output:
+  defaced:
+    - - meta:
+          type: map
+          description: |
+            Groovy Map containing sample information.
+            Expected keys for this module currently include `subject` and `session`,
+            for example `[ subject: '01', session: '001' ]`.
+      - sub-${meta.subject}/ses-${meta.session}/anat/*_defaced.nii.gz: {}
+  versions_pydeface:
+    - - "${task.process}":
+          type: string
+          description: The name of the process.
+      - "pydeface":
+          type: string
+          description: The name of the tool.
+      - "pydeface_version":
+          type: string
+          description: The version of PyDeface used by the process.
+tools:
+  - "pydeface":
+      description: "A tool to remove facial structure from MRI images."
+      homepage: "https://www.poldracklab.org"
+      documentation: "https://github.com/poldracklab/pydeface"
+      tool_dev_url: "https://github.com/poldracklab/pydeface"
+      doi: "10.5281/zenodo.6856482"
+      licence:
+        - "MIT"
+      identifier: ""
+topics:
+  versions:
+    - - "${task.process}":
+          type: string
+          description: The name of the process.
+      - "pydeface":
+          type: string
+          description: The name of the tool.
+  '"versions"':
+    - versions.yml:
+        type: string
+        description: The name of the process.
diff --git a/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test b/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test
new file mode 100644
index 00000000..82ebbf88
--- /dev/null
+++ b/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test
@@ -0,0 +1,115 @@
+nextflow_process {
+
+    name "Test Process PYDEFACE"
+    script "../main.nf"
+    process "PYDEFACE"
+    config "./nextflow.config"
+
+    tag "modules"
+    tag "modules_nfneuro"
+    tag "pydeface"
+    tag "anonymization"
+    tag "anonymization/pydeface"
+
+    tag "subworkflows"
+    tag "subworkflows/load_test_data"
+
+
+    test("single T1w nifti creates defaces image and logs") {
+        setup {
+            run("LOAD_TEST_DATA", alias: "LOAD_DATA") {
+                script "../../../../../subworkflows/nf-neuro/load_test_data/main.nf"
+                process {
+                    """
+                    input[0] = channel.from( ["T1w.zip"] )
+                    input[1] = "test.load-test-data"
+                    """
+                }
+            }
+        }
+
+
+        when {
+            process {
+                """
+                ch_t1w = LOAD_DATA.out.test_data_directory
+                    .filter{ it.simpleName == "T1w" }
+                    .map{ test_data_directory -> [
+                        [ subject: '01', session: '001' ],
+                        file("\${test_data_directory}/T1w.nii.gz")
+                    ] }
+
+                input[0] = ch_t1w
+                """
+
+            }
+        }
+
+        then {
+
+            // check if test case succeeded
+            assert process.success
+
+            // exactly one file per input nifti for normal output and publish output
+            assert process.out.defaced.size() == 1
+
+            // logs should exist
+            assert process.out.logs.size() >= 1
+
+            // helper functions
+            def asList = { x ->
+                x instanceof Collection ? x as List : [x]
+            }
+
+            def flatten = { xs ->
+                xs.collectMany { it instanceof Collection ? it as List : [it] }
+            }
+
+            def basename = { x ->
+                new File(x.toString()).name
+            }
+
+            def exists = { x ->
+                new File(x.toString()).exists()
+            }
+
+            def fileSize = { x ->
+                new File(x.toString()).length()
+            }
+
+            // get all module outputs
+            def meta = process.out.defaced[0][0]
+            def defacedFiles = asList(process.out.defaced[0][1])
+            def logFiles = flatten(process.out.logs)
+
+            // check meta data
+            assert meta.subject == '01'
+            assert meta.session == '001'
+
+            // defaced output check
+            assert defacedFiles.size() == 1
+            assert basename(defacedFiles[0]) == 'T1w_defaced.nii.gz'
+            assert exists(defacedFiles[0])
+            assert fileSize(defacedFiles[0]) > 0
+
+            // logs check
+            assert logFiles.collect { basename(it) }.sort() == [
+                'sub-01_ses-001_T1w_err.log',
+                'sub-01_ses-001_T1w_out.log'
+            ]
+
+            assert logFiles.every { exists(it) }
+
+            assert snapshot(
+                [
+                    meta: [
+                        subject: meta.subject,
+                        session: meta.session
+                    ],
+                    defaced: defacedFiles.collect { basename(it) }.sort(),
+                    logs: logFiles.collect { basename(it) }.sort()
+                ]
+            ).match("pydeface_outputs")
+        }
+    }
+}
diff --git a/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test.snap b/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test.snap
new file mode 100644
index 00000000..1e38c931
--- /dev/null
+++ b/modules/nf-neuro/anonymization/pydeface/tests/main.nf.test.snap
@@ -0,0 +1,24 @@
+{
+    "pydeface_outputs": {
+        "content": [
+            {
+                "meta": {
+                    "subject": "01",
+                    "session": "001"
+                },
+                "defaced": [
+                    "T1w_defaced.nii.gz"
+                ],
+                "logs": [
+                    "sub-01_ses-001_T1w_err.log",
+                    "sub-01_ses-001_T1w_out.log"
+                ]
+            }
+        ],
+        "meta": {
+            "nf-test": "0.9.3",
+            "nextflow": "26.04.4"
+        },
+        "timestamp": "2026-06-23T15:55:55.012676904"
+    }
+}
\ No newline at end of file
diff --git a/modules/nf-neuro/anonymization/pydeface/tests/nextflow.config b/modules/nf-neuro/anonymization/pydeface/tests/nextflow.config
new file mode 100644
index 00000000..a369251b
--- /dev/null
+++ b/modules/nf-neuro/anonymization/pydeface/tests/nextflow.config
@@ -0,0 +1,27 @@
+params.pydeface_cpus = 1
+params.pydeface_mem  = '3 GB'
+params.pydeface_time = '1h'
+
+process {
+    cpus = 1
+}
+
+trace {
+    enabled = false
+    overwrite = true
+}
+
+timeline {
+    enabled = false
+    overwrite = true
+}
+
+report {
+    enabled = false
+    overwrite = true
+}
+
+dag {
+    enabled = false
+    overwrite = true
+}