diff --git a/bellows/ash.py b/bellows/ash.py
index e278006a..9b4532b2 100644
--- a/bellows/ash.py
+++ b/bellows/ash.py
@@ -366,6 +366,7 @@ def __init__(self, ezsp_protocol) -> None:
 
         self._ncp_reset_code: t.NcpResetCode | None = None
         self._ncp_state: NcpState = NcpState.CONNECTED
+        self._in_reject_condition: bool = False
 
     def connection_made(self, transport):
         self._transport = transport
@@ -393,6 +394,22 @@ def close(self):
             self._transport.close()
             self._transport = None
 
+    def _reject_frame(self) -> None:
+        """Send NAK and enter reject condition if not already rejected."""
+        if self._ncp_state == NcpState.CONNECTED and not self._in_reject_condition:
+            _LOGGER.debug("Entering reject condition, sending NAK")
+            with contextlib.suppress(NcpFailure):
+                self._write_frame(NakFrame(res=0, ncp_ready=0, ack_num=self._rx_seq))
+            self._in_reject_condition = True
+        elif self._in_reject_condition:
+            _LOGGER.debug("Already in reject condition, suppressing NAK")
+
+    def _clear_reject_condition(self) -> None:
+        """Clear reject condition and allow future error responses."""
+        if self._in_reject_condition:
+            _LOGGER.debug("Clearing reject condition")
+            self._in_reject_condition = False
+
     @staticmethod
     def _stuff_bytes(data: bytes) -> bytes:
         """Stuff bytes for transmission"""
@@ -473,11 +490,12 @@ def data_received(self, data: bytes) -> None:
                         "Failed to parse frame %r", frame_bytes, exc_info=True
                     )
 
-                    with contextlib.suppress(NcpFailure):
-                        self._write_frame(
-                            NakFrame(res=0, ncp_ready=0, ack_num=self._rx_seq),
-                            prefix=(Reserved.CANCEL,),
-                        )
+                    # Reject DATA frame parse errors (SDK behavior)
+                    if (
+                        len(data) > 0
+                        and (data[0] & DataFrame.MASK) == DataFrame.MASK_VALUE
+                    ):
+                        self._reject_frame()
                 else:
                     self.frame_received(frame)
             elif reserved_byte == Reserved.CANCEL:
@@ -544,14 +562,18 @@ def data_frame_received(self, frame: DataFrame) -> None:
             self._rx_seq = (frame.frm_num + 1) % 8
             self._write_frame(AckFrame(res=0, ncp_ready=0, ack_num=self._rx_seq))
 
+            # Clear reject condition on valid in-sequence DATA frame
+            self._clear_reject_condition()
+
             self._ezsp_protocol.data_received(frame.ezsp_frame)
         elif frame.re_tx:
             # Retransmitted frames must be immediately ACKed even if they are out of
             # sequence
             self._write_frame(AckFrame(res=0, ncp_ready=0, ack_num=self._rx_seq))
         else:
-            _LOGGER.debug("Received an out of sequence frame: %r", frame)
-            self._write_frame(NakFrame(res=0, ncp_ready=0, ack_num=self._rx_seq))
+            # Out-of-sequence non-retransmitted frame: reject it
+            _LOGGER.debug("Received out-of-sequence frame: %r", frame)
+            self._reject_frame()
 
     def rstack_frame_received(self, frame: RStackFrame) -> None:
         self._ncp_reset_code = None
@@ -559,6 +581,7 @@ def rstack_frame_received(self, frame: RStackFrame) -> None:
 
         self._tx_seq = 0
         self._rx_seq = 0
+        self._clear_reject_condition()
         self._cancel_pending_data_frames(NcpFailure(code=frame.reset_code))
         self._change_ack_timeout(T_RX_ACK_INIT)
         self._ezsp_protocol.reset_received(frame.reset_code)
@@ -572,6 +595,7 @@ def nak_frame_received(self, frame: NakFrame) -> None:
     def rst_frame_received(self, frame: RstFrame) -> None:
         self._ncp_reset_code = None
         self._ncp_state = NcpState.CONNECTED
+        self._clear_reject_condition()
 
     def error_frame_received(self, frame: ErrorFrame) -> None:
         _LOGGER.debug("NCP has entered failed state: %s", frame.reset_code)
diff --git a/tests/test_ash.py b/tests/test_ash.py
index e1071815..f97b2c4f 100644
--- a/tests/test_ash.py
+++ b/tests/test_ash.py
@@ -639,6 +639,193 @@ async def test_rstack_cancels_pending_frames() -> None:
     assert exc_info.value.code == t.NcpResetCode.RESET_POWER_ON
 
 
+async def test_reject_condition_prevents_nak_amplification(caplog) -> None:
+    """Test that reject condition prevents NAK amplification on repeated errors."""
+    caplog.set_level(logging.DEBUG)
+
+    ezsp = MagicMock()
+    protocol = ash.AshProtocol(ezsp)
+    transport = MagicMock()
+    transport.is_closing.return_value = False
+    protocol.connection_made(transport)
+
+    # Start connected
+    protocol._ncp_state = ash.NcpState.CONNECTED
+
+    # Send first bad DATA frame with invalid CRC (control byte 0x00 = DATA frame)
+    bad_frame_1 = b"\x00Some bad data\xDE\xAD"  # Invalid CRC
+    protocol.data_received(bad_frame_1 + bytes([ash.Reserved.FLAG]))
+
+    # Should enter reject condition and send one NAK
+    assert "Entering reject condition" in caplog.text
+    nak_calls = [
+        c
+        for c in transport.write.mock_calls
+        if c.args and (c.args[0][0] & ash.NakFrame.MASK) == ash.NakFrame.MASK_VALUE
+    ]
+    assert len(nak_calls) == 1
+
+    caplog.clear()
+    transport.write.reset_mock()
+
+    # Send second bad DATA frame with invalid CRC
+    bad_frame_2 = b"\x00More bad data\xBE\xEF"  # Invalid CRC
+    protocol.data_received(bad_frame_2 + bytes([ash.Reserved.FLAG]))
+
+    # Should suppress NAK due to reject condition
+    assert "Already in reject condition" in caplog.text
+    assert len(transport.write.mock_calls) == 0
+
+    caplog.clear()
+
+    # Send third bad DATA frame with invalid CRC
+    bad_frame_3 = b"\x00Even more bad data\xCA\xFE"  # Invalid CRC
+    protocol.data_received(bad_frame_3 + bytes([ash.Reserved.FLAG]))
+
+    # Still suppressing
+    assert "Already in reject condition" in caplog.text
+    assert len(transport.write.mock_calls) == 0
+
+    caplog.clear()
+
+    # Send valid in-sequence DATA frame to clear reject condition
+    protocol._rx_seq = 0
+    good_frame = ash.DataFrame(frm_num=0, re_tx=0, ack_num=0, ezsp_frame=b"good")
+    protocol.data_received(good_frame.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Should clear reject condition and send ACK
+    assert "Clearing reject condition" in caplog.text
+    assert protocol._in_reject_condition is False
+
+    caplog.clear()
+    transport.write.reset_mock()
+
+    # Now another bad frame should trigger reject condition again
+    bad_frame_4 = b"\x00Bad again\xFA\xDE"  # Invalid CRC
+    protocol.data_received(bad_frame_4 + bytes([ash.Reserved.FLAG]))
+
+    # Should enter reject condition again and send NAK
+    assert "Entering reject condition" in caplog.text
+    nak_calls = [
+        c
+        for c in transport.write.mock_calls
+        if c.args and (c.args[0][0] & ash.NakFrame.MASK) == ash.NakFrame.MASK_VALUE
+    ]
+    assert len(nak_calls) == 1
+
+
+async def test_reject_condition_out_of_sequence_frames(caplog) -> None:
+    """Test that reject condition prevents NAK amplification on out-of-sequence frames."""
+    caplog.set_level(logging.DEBUG)
+
+    ezsp = MagicMock()
+    protocol = ash.AshProtocol(ezsp)
+    transport = MagicMock()
+    transport.is_closing.return_value = False
+    protocol.connection_made(transport)
+
+    protocol._ncp_state = ash.NcpState.CONNECTED
+    protocol._rx_seq = 3  # Expecting frame 3
+
+    # Send out-of-sequence frame 4 (not retransmitted)
+    frame_4 = ash.DataFrame(frm_num=4, re_tx=0, ack_num=0, ezsp_frame=b"frame 4")
+    protocol.data_received(frame_4.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Should enter reject condition and send NAK
+    assert "Entering reject condition" in caplog.text
+    assert protocol._in_reject_condition is True
+    nak_calls = [
+        c
+        for c in transport.write.mock_calls
+        if c.args and (c.args[0][0] & ash.NakFrame.MASK) == ash.NakFrame.MASK_VALUE
+    ]
+    assert len(nak_calls) == 1
+
+    caplog.clear()
+    transport.write.reset_mock()
+
+    # Send another out-of-sequence frame 5
+    frame_5 = ash.DataFrame(frm_num=5, re_tx=0, ack_num=0, ezsp_frame=b"frame 5")
+    protocol.data_received(frame_5.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Should suppress NAK due to reject condition
+    assert "Already in reject condition" in caplog.text
+    assert len(transport.write.mock_calls) == 0
+
+    # Send another out-of-sequence frame 6
+    frame_6 = ash.DataFrame(frm_num=6, re_tx=0, ack_num=0, ezsp_frame=b"frame 6")
+    protocol.data_received(frame_6.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Still suppressing
+    assert len(transport.write.mock_calls) == 0
+
+    caplog.clear()
+
+    # Finally send the expected frame 3
+    frame_3 = ash.DataFrame(frm_num=3, re_tx=0, ack_num=0, ezsp_frame=b"frame 3")
+    protocol.data_received(frame_3.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Should clear reject condition
+    assert "Clearing reject condition" in caplog.text
+    assert protocol._in_reject_condition is False
+
+
+async def test_reject_condition_retransmitted_frames_always_acked() -> None:
+    """Test that retransmitted out-of-sequence frames are ACKed without entering reject."""
+    ezsp = MagicMock()
+    protocol = ash.AshProtocol(ezsp)
+    transport = MagicMock()
+    transport.is_closing.return_value = False
+    protocol.connection_made(transport)
+
+    protocol._ncp_state = ash.NcpState.CONNECTED
+    protocol._rx_seq = 3  # Expecting frame 3
+
+    # Send out-of-sequence retransmitted frame (re_tx=1)
+    retx_frame = ash.DataFrame(frm_num=4, re_tx=1, ack_num=0, ezsp_frame=b"retx")
+    protocol.data_received(retx_frame.to_bytes() + bytes([ash.Reserved.FLAG]))
+
+    # Should send ACK, not NAK, and not enter reject condition
+    assert protocol._in_reject_condition is False
+    ack_calls = [
+        c
+        for c in transport.write.mock_calls
+        if c.args and (c.args[0][0] & ash.AckFrame.MASK) == ash.AckFrame.MASK_VALUE
+    ]
+    assert len(ack_calls) >= 1
+
+
+async def test_reject_condition_firmware_amplification_bug() -> None:
+    """Test reject condition prevents OpenThread RCP amplification."""
+    ezsp = MagicMock()
+    protocol = ash.AshProtocol(ezsp)
+    transport = MagicMock()
+    transport.is_closing.return_value = False
+    protocol.connection_made(transport)
+
+    protocol._ncp_state = ash.NcpState.CONNECTED
+
+    # Simulate firmware sending garbage that happens to end with ~
+    protocol.data_received(b"\x00\x06p1A A0 54 1A]\n\x07K~")
+
+    # ASH enters reject condition and sends a NAK
+    assert len(transport.write.mock_calls) == 1
+
+    transport.write.reset_mock()
+
+    # Firmware responds to the NAK with yet another corrupt frame
+    protocol.data_received(b"\x00\x06pFraming error 6: [\xca\xfd~")
+
+    # We no longer reply, as we are in a reject condition
+    assert len(transport.write.mock_calls) == 0
+
+    # Firmware sends yet another corrupt response
+    protocol.data_received(b"\x00\x06p1A A0 54 1A]\n\x07K~")
+
+    # Still suppressing - no amplification
+    assert len(transport.write.mock_calls) == 0
+
+
 def test_ncp_failure_comparison() -> None:
     exc1 = ash.NcpFailure(code=t.NcpResetCode.ERROR_EXCEEDED_MAXIMUM_ACK_TIMEOUT_COUNT)
     exc2 = ash.NcpFailure(code=t.NcpResetCode.RESET_POWER_ON)