Drug Research Opioid and SSRI Interactions

gatsby-config.js

@@ -1,4 +1,5 @@
 module.exports = {
+  pathPrefix: `/opioid-and-ssri`,
   siteMetadata: {
     title: `openFDA`,
     siteUrl: `https://www.open.fda.gov`,

package.json

@@ -5,10 +5,10 @@
   "author": "Violet Wren, Priyanka Ayer",
   "scripts": {
     "dev": "gatsby develop -H 0.0.0.0 -p 3000",
-    "serve": "gatsby serve -H 0.0.0.0 -p 3000",
-    "build": "gatsby build --verbose",
+    "serve": "gatsby serve --prefix-paths -H 0.0.0.0 -p 3000",
+    "build": "gatsby build --prefix-paths --verbose",
     "format": "prettier --trailing-comma es5 --no-semi --single-quote --write 'src/**/*.{js,ts,tsx}'",
-    "develop": "gatsby develop",
+    "develop": "gatsby develop --prefix-paths",
     "cy:open": "cypress open",
     "cy:run": "cypress run",
     "test:e2e": "start-server-and-test dev http-get://127.0.0.1:3000 cy:open",

src/components/ApiStatus.tsx

@@ -22,6 +22,7 @@ let endpointKeys = [
   'drugorangebook',
   'drugsfda',
   'drugshortages',
+  'drugresearchopioidandssri',
   'deviceevent',
   'devicerecall',
   'deviceclass',
@@ -56,6 +57,7 @@ const catMap: Record<EndpointKey, string> = Object.freeze({
   'drugenforcement': 'Drugs › Enforcement Reports',
   'drugsfda': 'Drugs › Drugs@FDA',
   'drugshortages': 'Drugs › Drug Shortages',
+  'drugresearchopioidandssri': 'Drugs › Opioid and SSRI Interactions Research',
   'deviceevent': 'Devices › Adverse Events',
   'devicerecall': 'Devices › Recalls',
   'deviceclass': 'Devices › Classification',
@@ -89,6 +91,7 @@ const endpointLinkMap: Record<EndpointKey, string> = Object.freeze({
   'drugorangebook': 'drug/orangebook',
   'drugsfda': 'drug/drugsfda',
   'drugshortages': 'drug/shortages',
+  'drugresearchopioidandssri': 'drug/researchopioidandssri',
   'deviceevent': 'device/event',
   'devicerecall': 'device/recall',
   'deviceclass': 'device/classification',

src/components/ApiUsage.tsx

@@ -453,6 +453,7 @@ if (!bp.mob && hasWindow) {
                       <tr><td>Orange Book</td><td>{this.docCount('drugorangebook')}</td></tr>
                       <tr><td>Drugs@FDA</td><td>{this.docCount('drugsfda')}</td></tr>
                       <tr><td>Drug Shortages</td><td>{this.docCount('drugshortages')}</td></tr>
+                      <tr><td>Opioid and SSRI Interactions Research</td><td>{this.docCount('drugresearchopioidandssri')}</td></tr>
 
                       <tr className='bg-primary-darkest clr-white'><td colSpan={2}><strong>Foods</strong></td></tr>
                       <tr><td>Adverse Event Reports</td><td>{this.docCount('foodevent')}</td></tr>
@@ -516,6 +517,7 @@ if (!bp.mob && hasWindow) {
                       <tr><td>Orange Book</td><td>{this.downloadCount('drugorangebook')}</td></tr>
                       <tr><td>Drugs@FDA</td><td>{this.downloadCount('drugsfda')}</td></tr>
                       <tr><td>Drug Shortages</td><td>{this.downloadCount('drugshortages')}</td></tr>
+                      <tr><td>Opioid and SSRI Interactions Research</td><td>{this.downloadCount('drugresearchopioidandssri')}</td></tr>
 
                       <tr className='bg-primary-darkest clr-white'><td colSpan={2}><strong>Foods</strong></td></tr>
                       <tr><td>Adverse Event Reports</td><td>{this.downloadCount('foodevent')}</td></tr>

src/components/DataDictionary.tsx

@@ -104,6 +104,7 @@ class DataDictionary extends React.Component<{}, DataDictionaryState> {
       'orangebook': 'Orange Book',
       'drugsfda': 'Drugs@FDA',
       'drugshortages': 'Drug Shortages',
+      'researchopioidandssri': 'Opioid and SSRI Interactions Research ',
       'covid19serology': 'COVID-19 Serology',
       'pma': 'Pre-Market Approval',
       'recall': 'Recall',

src/components/EndpointBox.tsx

@@ -52,7 +52,8 @@ const EndpointBox = (props: endpointBoxProps) => {
       'enforcement': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-rotate-left' style={{ color: "white" }} /></div>,
       'drugsfda': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-at' style={{ color: "white" }} /></div>,
       'drugshortages': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-angle-double-down' style={{ color: "white" }} /></div>,
-      'orangebook': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-book' style={{ color: "white" }} /></div>
+      'orangebook': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-book' style={{ color: "white" }} /></div>,
+      'researchopioidandssri': <div className='ep-icon' style={bg_color.drug}><i className='fa fa-3x fa-book' style={{ color: "white" }} /></div>
     },
     'other': {
       'historicaldocument': <div className="ep-icon" style={bg_color['other']}><i className="fa fa-3x fa-history" style={{ color: "white" }} /></div>,

src/components/Footer.tsx

@@ -70,7 +70,7 @@ class Footer extends React.Component {
                 <img
                   alt='Go to FDA website'
                   width='180px'
-                  src={"/img/gov-fda-new-white.svg"}
+                  src={withPrefix("/img/gov-fda-new-white.svg")}
                 />
               </a>
             </li>

src/components/Layout.tsx

@@ -37,7 +37,10 @@ const Layout = (props: LayoutProps) => {
     up: 'sticky-scroll-up'
   }
 
-  const hasSidebar = props.location.pathname.slice(0, 6) === `/apis/`
+  console.log(props.location.pathname)
+  console.log(props.location.pathname.slice(0, 23))
+  const hasSidebar = props.location.pathname.slice(0, 6) === `/apis/` || props.location.pathname.slice(0, 24) === `/drug-cbd-research/apis/`
+  // const hasSidebar = props.location.pathname.slice(0, 6) === `/apis/`
   return (
     <DocumentTitle title='openFDA' key='openFDA'>
       <div>

src/components/RenderContentObject/KeyFacts.tsx

@@ -35,7 +35,8 @@ const source: Record<string, Record<string, string>> = {
     'enforcement': 'FDA Recall Enterprise System (RES)',
     'orangebook': 'Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book)',
     'drugsfda': 'Drugs@FDA',
-    'shortages': 'Drug Shortages'
+    'shortages': 'Drug Shortages',
+    'researchopioidandssri': 'Opioid and SSRI Interactions Research'
   },
   'other': {
     'historicaldocument': 'Historic FDA Press Releases',
@@ -80,7 +81,8 @@ const sourceLink: any = {
     'enforcement': '/data/res/',
     'orangebook': '/data/orangebook/',
     'drugsfda': '/data/drugsfda/',
-    'shortages': '/data/drugshortages'
+    'shortages': '/data/drugshortages/',
+    'researchopioidandssri': '/data/researchopioidandssri/'
   },
   'other': {
     'historicaldocument': '/data/historicaldocument/',
@@ -127,7 +129,8 @@ const timePeriod: any = {
     'enforcement': '2004 to',
     'orangebook': 'Content current as of:',
     'drugsfda': '1939 to',
-    'shortages': '2012 to'
+    'shortages': '2012 to',
+    'researchopioidandssri': 'Last updated'
   },
   'other': {
     'historicaldocument': '1913 to',
@@ -175,7 +178,8 @@ const frequency = {
     'enforcement': 'Weekly',
     'orangebook': 'Monthly',
     'drugsfda': 'Daily (Monday-Friday)',
-    'shortages': 'Daily'
+    'shortages': 'Daily',
+    'researchopioidandssri': 'Infrequently'
   },
   'other': {
     'historicaldocument': 'Infrequently',

src/constants/api.tsx

@@ -1,4 +1,6 @@
-export const API_LINK: string = "https://api.fda.gov"
+// export const API_LINK: string = "https://api.fda.gov"
+export const API_LINK: string = "https://openfda-api.preprod.fda.gov"
+// export const API_LINK: string = "http://54.196.38.238:8000"
 export const API_NAME: string = "api.fda.gov"
 export default {
   API_LINK,

src/constants/endpoint_box.ts

@@ -31,7 +31,8 @@ export const description: Record<NounName, Partial<Record<EndpointName, string>>
     'enforcement': 'Drug product recall enforcement reports.',
     'orangebook': 'Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book).',
     'drugsfda': 'Drugs@FDA includes most of the drug products approved since 1939.',
-    'drugshortages': 'Drug Shortages can occur for many reasons, including manufacturing and quality problems, delays, and discontinuations.'
+    'drugshortages': 'Drug Shortages can occur for many reasons, including manufacturing and quality problems, delays, and discontinuations.',
+    'researchopioidandssri': 'This dataset makes available the research paper "Cannabidiol and Liver Enzyme Level Elevations in Healthy Adults".'
 },
   'other': {
     'historicaldocument': 'FDA Press Releases, 1913-2014, in searchable format',
@@ -79,7 +80,8 @@ export const ep_title: Record<NounName, Partial<Record<EndpointName, string>>> =
     'enforcement': 'Recall enforcement reports',
     'orangebook': 'Orange Book',
     'drugsfda': 'Drugs@FDA',
-    'drugshortages': 'Drug shortages'
+    'drugshortages': 'Drug shortages',
+    'researchopioidandssri': 'Opioid and SSRI Interactions Research'
   },
   'other': {
     'historicaldocument': 'Historical Documents',
@@ -137,7 +139,8 @@ export const ep_path: Record<NounName, Partial<Record<EndpointName, string>>> =
     'enforcement': '/apis/drug/enforcement/',
     'orangebook': '/apis/drug/orangebook/',
     'drugsfda': '/apis/drug/drugsfda/',
-    'drugshortages': '/apis/drug/drugshortages/'
+    'drugshortages': '/apis/drug/drugshortages/',
+    'researchopioidandssri': '/apis/drug/researchopioidandssri/'
   },
   'other': {
     'historicaldocument': '/apis/other/historicaldocument/',

src/constants/fields/drugresearchopioidandssri.yaml

@@ -0,0 +1,189 @@
+properties:
+  subject_id:
+    description: "Participant ID"
+    format:
+    is_exact: true
+    possible_values:
+    type: string
+  age:
+    description: "Age of the participant (unit = years)"
+    format:
+    is_exact: true
+    possible_values:
+    type: integer
+  sex:
+    description: "Sex of the participant (one of 'Female' or 'Male')"
+    format:
+    is_exact: true
+    possible_values:
+    type: string
+  ethnicity:
+    description: "Ethnicity of the participant (one of 'Hispanic or Latino' or 'Not Hispanic or Latino')"
+    format:
+    is_exact: true
+    possible_values:
+    type: string
+  race:
+    description: "Race of the participant (one of ‘American Indian or Alaska Native’, 'Asian', 'Black or African American', ‘Multiple’, ‘Unknown’, or 'White')"
+    format:
+    is_exact: true
+    possible_values:
+    type: string
+  height:
+    description: "Height of the participant (unit = cm)"
+    format:
+    is_exact: true
+    possible_values:
+    type: integer
+  weight:
+    description: "Weight of the participant (unit = kg)"
+    format:
+    is_exact: true
+    possible_values:
+    type: number
+  body_mass_index:
+    description: "Body mass index of the participant (unit = kg/m2)"
+    format:
+    is_exact: true
+    possible_values:
+    type: number
+  treatment:
+    description: "Type of treatment (one of CBD = “Cannabidiol”; PLB = “Placebo”)"
+    format:
+    is_exact: true
+    possible_values:
+    type: string
+  primary_event_flag:
+    description: "Flag for if the participant had an event meeting criteria for the primary endpoint"
+    format:
+    is_exact: true
+    possible_values:
+    type: boolean
+  secondary_event_flag:
+    description: "Flag for if the participant had an event meeting criteria for the secondary endpoint"
+    format:
+    is_exact: true
+    possible_values:
+    type: boolean
+  discontinued_no_event:
+    description: "Flag for if the participant discontinued before the end of the study for reasons other than liver enzyme elevations (i.e., for non-liver safety, withdrawal of consent, lack of adherence, etc.)"
+    format:
+    is_exact: true
+    possible_values:
+    type: boolean
+  start_day:
+    description: "Day treatment was initiated. (Day = 1 for all participants)"
+    format:
+    is_exact: true
+    possible_values:
+    type: integer
+  end_day:
+    description: "Last day study drug was administered"
+    format:
+    is_exact: true
+    possible_values:
+    type: integer
+  periods:
+    type: array
+    items:
+      type: object
+      properties:
+        period:
+          description: "Study period when data was collected. One of 1, 2, or 3."
+          format:
+          is_exact: true
+          possible_values:
+          type: string
+        days:
+          type: array
+          items:
+            type: object
+            properties:
+              day:
+                description: "Nominal study day (unit = day)."
+                format:
+                is_exact: true
+                possible_values:
+                type: string
+              times:
+                type: array
+                items:
+                  type: object
+                  properties:
+                    time:
+                      description: "Nominal sampling time (unit = hour)."
+                      format:
+                      is_exact: true
+                      possible_values:
+                      type: string
+                    analytes:
+                      type: array
+                      items:
+                        type: object
+                        properties:
+                          analyte:
+                            description: "Measured analyte. One of Oxycodone, Oxymorphone, Paroxetine, Escitalopram, Desmethylescitalopram, and Didesmethylescitalopram."
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: string
+                          drug:
+                            description: 'Administered co-drug with oxycodone. One of "Placebo", "Escitalopram" and "Paroxetine".'
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: string
+                          concentration:
+                            description: "Reported concentration with values below lower limit of quantification set to zero. (unit = ng/mL)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+                    mixtures:
+                      type: array
+                      items:
+                        type: object
+                        properties:
+                          mixture:
+                            description: "Type of hypercapnic gas mixture in rebreathing bag. One of hyperoxic (24% O2, 6% CO2, N2 balanced) or hypoxic (6% O2, 6% CO2, N2 balanced)."
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: string
+                          drug:
+                            description: 'Administered co-drug with oxycodone. One of "Placebo", "Escitalopram" and "Paroxetine".'
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: string
+                          mvresting:
+                            description: "Resting minute ventilation (unit=L/min)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+                          etco2:
+                            description: "Resting end-tidal carbon dioxide partial pressure (unit=mm Hg)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+                          spo2:
+                            description: "Resting oxygen saturation (unit=%)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+                          ve55:
+                            description: "Minute ventilation assessment at 55 mm Hg carbon dioxide. (unit=L/min)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+                          vas_score:
+                            description: "Visual analogue score for sedation (range of 0 to 100) (unit=mm)"
+                            format:
+                            is_exact: true
+                            possible_values:
+                            type: number
+type: object