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Address some of the reviewers' comments#80

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TuomasBorman merged 6 commits into
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Apr 8, 2026
Merged

Address some of the reviewers' comments#80
TuomasBorman merged 6 commits into
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@TuomasBorman

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Comment thread manuscript.qmd Outdated
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Comment thread manuscript.qmd
yet flexible workflows. In particular, the direct interoperability with the
yet flexible workflows, as TreeSE inherits full compatibility with methods
designed for SE. In particular, the direct interoperability with the
widely adopted SE data science ecosystem distinguishes our TreeSE-based

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This highlights that all methods that are using SE can be used with TreeSE.

We could consider highlighting SummarizedExperiment more (instead of TreeSE, we could talk about SE). It would emphasize that this framework is integrated to SE ecosystem

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Ehkä se olisi hyvä. Ja sit esitetään TreeSE laajennuksena siihen.

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omics data sets [@huber2015; @ramos2017; @amezquita2020]. By leveraging
standardized multi-assay data structures, users can apply a growing
number of integrative methods for multi-omics analysis. This eliminates the
need for manual data wrangling, reduces the risk of errors (*e.g.*, sample
mismatches), and enables the creation of modular, efficient, and reproducible
workflows. Such integrative approaches in microbiome

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This highlights more the benefits of MultiAssayExperiment

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Could be added more examples on methods that are supporting MAE

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microbiome data [@benedetti2025]. The former extends iSEE to provide support for
TreeSE objects, while the latter builds on iSEEtree to enable analyses without
requiring any programming. Their interface supports automatic generation of
source code and replicable workflows as well as analysis templates for users
without a strong programming expertise. Moreover, the tidy R paradigm, available

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Reviewer said that it is not clear how iSEEtree and miaDash relates to iSEE

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We can clarify that iSEEtree is a generic extension of iSEE for hierarchical data, whereas miaDash is a specific application of iSEEtree for code-free microbiome analysis.

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Can you @RiboRings suggest improvements to text once this PR is merged?

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@antagomir
antagomir self-requested a review April 5, 2026 10:04
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microbiome data [@benedetti2025]. The former extends iSEE to provide support for
TreeSE objects, while the latter builds on iSEEtree to enable analyses without
requiring any programming. Their interface supports automatic generation of
source code and replicable workflows as well as analysis templates for users
without a strong programming expertise. Moreover, the tidy R paradigm, available

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Comment thread manuscript.qmd Outdated
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and application of modular, interoperable statistical workflows. Here we present
a R/Bioconductor ecosystem for microbiome data science. While TreeSE and MAE are
prior contributions, we have built an ecosystem around them through further
method and community development. We also provide a comprehensive online book

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specifically serving the microbiome data science community

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Mihin kohtaan tämä oli? En saanut tätä sopimaan.

@TuomasBorman

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Summary of things that need to be still refined:

  1. Update multi-omics section
    • Could be added more about new methods. For instance, citation to mixOmics as it is expected that they will add the support for MAE soon
  2. Consider using SE instead of TreeSE
    • This would emphasize the interoperability across Bioconductor.
    • I emphasized it more that TreeSE is SE. In addition, we could use SE in text instead of TreeSE, but it might become confusing.
  3. Update analytical framework comparison
  4. @RiboRings Update iSEE/miaDash part

@TuomasBorman
TuomasBorman merged commit 52faf7c into devel Apr 8, 2026
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@TuomasBorman
TuomasBorman deleted the review branch April 8, 2026 06:22
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3 participants